Sildenafil Citrate (Viagra) Raw Powder
Sildenafil Citrate (Viagra)
Brief info:Sildenafil citrate
CAS: 171599-83-0
Assay: 99% min. USP32
Packing: 1kg/foil bag, 5kg/drum.
Delivery: Express courier.
MF: C28H38N6O11S
MW: 666.7
Character: White Solid. mp 187-189°C
Usage: An orally active selective type 5 cGMP phosphodiesterase inhibitor. pharmaceutical material
Biological Activity: Orally active, potent inhibitor of phosphodiesterase 5 (PDE5) (IC 50 = 4 nM). Enhances nitric oxide-dependent relaxation of human corpus cavernosum in vitro.
Description:
During sexual stimulation, the penis non-adrenergic non-cholinergic neuronal nitric oxide synthase and vascular endothelial L-arginine catalyzed synthesis of nitric oxide, which activate guanylate cyclase to make cyclic monophosphate guanosine synthesis, thereby giving rise to smooth muscle relaxation of corpus cavernosum smooth muscle, and small arteries, cavernous blood into the penis, so that penile erection. Meanwhile cyclic guanosine monophosphate and by hydrolysis of phosphodiesterase.
Thus, in theory, both to improve the guanylate cyclase activity or inhibiting phosphodiesterase activity, can increase the cGMP level, it helps penile corpus cavernosum smooth muscle and smooth muscle of small arteries relaxation. Viagra (sildenafil) is through inhibition of the hydrolytic activity of phosphodiesterase to increase cGMP levels without affecting cAMP, thereby increasing the sexual stimulation of nitric oxide synthase / cyclic guanosine monophosphate waterfall effect, so cavernous smooth muscle relaxation, to achieve the purpose of treatment of erectile dysfunction.
Dosage:
For most patients, the recommended dose is 50mg, in about 1 hour before sexual activity taking; but any time before sexual activity within 0.5 to 4 hours can be taken. Based on the efficacy and tolerability, the dose can be increased to 100 mg (the maximum recommended dose) or decreased to 25 mg. Maximum daily doses of 1.
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2. Ensure the discreet parcel and offer the suitable shipping method for reference.
3. The payment that you available for.
4. Shipped out until you paid 100% in advance.
5. Arrange the shipment according to your requirements.
6. Tracked the code when it is online.
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